APPLICATION OF ADAPTIVE CONTROL TECHNIQUE TO DIABETIC MANAGEMENT

Abstract

The theoretical and practical issues of a model reference adaptive system for simula- tion and optimization of insulin therapy in patients with insulin-dependent diabetes is described in this paper. The adaptive optimizer, denoted AdASDiM, can operate with sparse (3-5 times/day) blood glucose measurements in contrast to most of the similar adaptive blood glucose controllers which needs a relative high frequency of blood samples (2-30 times/hour) taken from the diabetic patient. In the absence of real data, a reference model behaving as a 'healthy subject' generates 'pseudo' blood glucose values. Also, the proposed scheme makes use of the knowledge of the time and quantity of future meals.